Crossing Zero: The Art & Science of Deprescribing with Anders Sorensen

Many people are told that their brain chemistry is permanently broken, making the idea of coming off psychiatric medication feel overwhelming or unsafe. But psychologist Anders Sorensen challenges this narrative, offering a fresh, evidence-based perspective on how these drugs actually work—and how to taper off them safely. In this eye-opening conversation, Sorensen breaks down the flawed assumptions behind the chemical imbalance theory and introduces his “hyperbolic tapering” method, which aligns with how antidepressants truly affect brain chemistry through SERT occupancy. Even low doses, he explains, can have powerful effects, which is why standard tapering methods often lead to withdrawal symptoms mistaken for relapse.

Sorensen’s new book, Crossing Zero: The Art and Science of Coming Off and Staying Off Psychiatric Drugs, blends clinical science with emotional insight to help people reframe their mental health journey. Rather than seeing medication as a lifelong necessity, he encourages a shift toward understanding these drugs as tools for emotional regulation—not permanent treatments. Therapists, too, have a vital role to play in this process, supporting clients through a tapering journey that has long been considered beyond their scope. This episode invites listeners to rethink long-held beliefs and explore new paths to healing.